Journal of Micromechanics and Microengineering
Evaluation of solvent releases from microfluidic devices made of cycloolefin polymer by temperature-desorption mass spectrometry
Seiichiro Takahashi 1, Yutaka Mune 2, Akihiko Yamamuro 1, Akira Aiba 2,
Kenji Hatakeyama 1 and Ken-ichiro Kamei 3,4,5,6
1 Organs On Chip Project, Business Creation Division, Ushio INC, 1-6-5 Marunouchi, Chiyoda-ku,
Tokyo 100-8150, Japan
2 Analysis Group, Fundamental Technology Department, Research and Development Division,
Ushio Inc., 1-6-5 Marunouchi, Chiyoda-ku, Tokyo 100-8150, Japan
3 Institute for Integrated Cell-Material Sciences (WPI-iCeMS), Kyoto University,
Yoshida-Ushinomiya-cho, Sakyo-ku, Kyoto 606-8501, Japan
4 Wuya College of Innovation, Shenyang Pharmaceutical University, Liaoning 110016, People’s Republic
of China
5 Department of Pharmaceutics, Shenyang Pharmaceutical University, Liaoning 110016, People’s
Republic of China
6 Programs of Biology and Bioengineering, Divisions of Science and Engineering, New York University
Abu Dhabi, United Arab Emirates
Kenji Hatakeyama 1 and Ken-ichiro Kamei 3,4,5,6
1 Organs On Chip Project, Business Creation Division, Ushio INC, 1-6-5 Marunouchi, Chiyoda-ku,
Tokyo 100-8150, Japan
2 Analysis Group, Fundamental Technology Department, Research and Development Division,
Ushio Inc., 1-6-5 Marunouchi, Chiyoda-ku, Tokyo 100-8150, Japan
3 Institute for Integrated Cell-Material Sciences (WPI-iCeMS), Kyoto University,
Yoshida-Ushinomiya-cho, Sakyo-ku, Kyoto 606-8501, Japan
4 Wuya College of Innovation, Shenyang Pharmaceutical University, Liaoning 110016, People’s Republic
of China
5 Department of Pharmaceutics, Shenyang Pharmaceutical University, Liaoning 110016, People’s
Republic of China
6 Programs of Biology and Bioengineering, Divisions of Science and Engineering, New York University
Abu Dhabi, United Arab Emirates
In this study, the release of solvents used in the manufacturing of microfluidic devices made of COP was evaluated. Devices with solvent bonding released solvent from the surface of the material at the temperature at which cell culture was performed, whereas devices with VUV bonding started to release a small amount of solvent at higher temperatures (above 84◦ C). It was therefore concluded that VUV bonding is a manufacturing method that does not affect cell culture compared to solvent bonding. Thus, the evaluation of the solvents and impurities released from microfluidic devices is essential before these devices can be applied to biological experiments. We believe that such assessments can help in the development of microfluidics by providing useful information for the selection of suitable materials and bonding processes for individual applications.
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