PRODUCTS
Nerve Plate
Nerve MPS & AI Imaging Analysis
Makes neurotoxicity evaluation simpler and more accurate.
Quantitatively predicts nerve disorder risks
using AI (artificial intelligence). Increases the efficiency of
drug screening.
FEATURE
Features
Making neurotoxicity evaluation simpler
and more accurate.
- Device suitable for neurite separation and imaging.
- Conducts peripheral nerve disorder evaluation with image analysis AI (artificial intelligence).
- Enables high throughput screening.
- Fabricated by Photobonding®, and medical grade COP.
TECHNOLOGY & METHODS
採用技術
- STEP1Cultivation nerve cells in the plate and neurites will outgrowth into the microchannel.
- STEP2After staining the nerve cells, observe them using HCS equipment or a fluorescence microscope.
- STEP3Analyze the image data with pretrained AI and predict the neurotoxity of drug candidates.
Microchannel Culture
Through microchannels with ultrathin openings, only neurites extend from the nerve cell aggregates. Moreover, uniform neurite formation is ensured and stabilized. In addition, clear images suitable for AI analysis can be obtained. Furthermore, similar to well plates, the chip is easy to handle through the use of micropipettes. Cumbersome tube connections are unnecessary. Automated equipment, such as automatic dispensing equipment and HCS equipment, can also be used in conjunction.
AI Imaging Analysis
The evaluation method was developed jointly with Prof. Ikurou Suzuki of Tohoku Institute of Technlogy.
It studies the structural characteristics of neurites during drug disorders and evaluates the risk of nerve disorders. It ensures a stable risk assessment, a suitable throughput, and automative workflow.
Our publications
1) Fundam. Toxicol. Sci., 9(7), 203, 2022.
2) Toxics 2023, 11, 848. https://doi.org/10.3390/toxics11100848
3) Toxics 2024, 12, 809. https://doi.org/10.3390/toxics12110809
All-in-one support
To obtain the best results in the shortest possible time,
we will perform contract testing or preliminary testing for your in-house implementation.
Collaboration with 
MODEL CASE
Model Cases
01
Peripheral Nerve Disorder
AI Evaluation Model
Making neurotoxicity evaluation simpler and more accurate.
- Enables high throughput of nerve cell evaluation.
- Design of devices suitable for neurite isolation and imaging.
- Conducts peripheral nerve disorder evaluation with image analysis AI (artificial intelligence).
- Fabrication by light bonding technology, Photobonding®, and medical grade COP. The resultant chip with no elution and low autofluorescence facilitates nerve cell experiments.
CONTACT
Please contact us to inquire about
our products or technical services.
PRODUCTS
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