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Nerve Plate

Channels for Culturing
Nerve Cells X AI Imaging Analysis

Makes neurotoxicity evaluation simpler and more accurate.
Quantitatively predicts nerve disorder risks
using AI (artificial intelligence). Increases the efficiency of
drug screening.

FEATURE

Features

Making neurotoxicity evaluation simpler and more accurate.

  • Enables high throughput of nerve cell evaluation.
  • Design of devices suitable for neurite isolation and imaging.
  • Conducts peripheral nerve disorder evaluation with image analysis AI (artificial intelligence).
  • Fabrication by light bonding technology, Photobonding®, and medical grade COP. The resultant chip with no elution facilitates nerve cell experiments.

METHODS

解析方法

  • STEP1Culture nerve cells in the nerve MPS plate and form neurites.
  • STEP2After staining the nerve cells, observe them using HCS equipment or a fluorescence microscope.
  • STEP3Analyze the image data with pretrained AI and assess the risk of nerve disorders.

AI image analysis of nerve disorders

TECHNOLOGY

採用技術

Microchannel culture

Microchannel Culture

Through microchannels with ultrathin openings, only neurites extend from the nerve cell aggregates. Moreover, uniform neurite formation is ensured and stabilized. In addition, clear images suitable for AI analysis can be obtained. Furthermore, similar to well plates, the chip is easy to handle through the use of micropipettes. Cumbersome tube connections are unnecessary. Automated equipment, such as automatic dispensing equipment and HCS equipment, can also be used in conjunction.

AI Imageing Analysis

AI Imaging Analysis

The AI evaluation system was developed jointly with Prof. Ikurou Suzuki of Tohoku Institute of Technlogy. It studies the structural characteristics of neurites during drug disorders and evaluates the risk of nerve disorders. It ensures a stable risk assessment and a suitable throughput for handling multiple specimens.

Reference Model Images of Known Drugs

Quantitative prediction of nerve disorder risks using AI (artificial intelligence). Increase of drug screening efficiency.

MODEL CASE

Model Cases

01

Peripheral Nerve Disorder
AI Evaluation Model

Making neurotoxicity evaluation simpler and more accurate.

  • Enables high throughput of nerve cell evaluation.
  • Design of devices suitable for neurite isolation and imaging.
  • Conducts peripheral nerve disorder evaluation with image analysis AI (artificial intelligence).
  • Fabrication by light bonding technology, Photobonding®, and medical grade COP. The resultant chip with no elution and low autofluorescence facilitates nerve cell experiments.

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