PLOS ONE Published: August 12, 2020
Exploratory clinical trial on the safety and bactericidal effect of 222-nm ultraviolet C irradiation in healthy humans
Tomoaki Fukui 1, Takahiro Niikura 1, Takahiro Oda 1, Yohei Kumabe 1, Hiroyuki Ohashi 2, Masahiro Sasaki 2, Tatsushi Igarashi 2, Makoto Kunisada 3, Nozomi Yamano 3, Keisuke Oe 1, Tomoyuki Matsumoto 1, Takehiko Matsushita 1, Shinya Hayashi 1, Chikako Nishigori 3, Ryosuke Kuroda 1
1 Department of Orthopaedic Surgery, Kobe University Graduate School of Medicine, Kobe, Hyogo, Japan.
2 Ushio Inc., Chiyoda-ku, Tokyo, Japan.
3 Division of Dermatology, Department of Internal Related, Kobe University Graduate School of Medicine, Kobe, Hyogo, Japan.
Conventionally, 254 nm UV-C has been mainly used as a germicidal lamp, however when it is directly irradiated to the human body, it can cause erythema and skin cancer. Whilst, UV radiation with wavelength of 222 nm has been reported that it is much safer than the conventionally used UV radiation with wavelength of 254 nm. According to this report, healthy volunteers were tested with the purpose of examining the safety of UV irradiation with wavelength of 222 nm and its sterilization action on the skin. When the presence or absence of skin erythema (i.e., an acute injury due to UV radiation) was examined 24 h after the end of irradiation, at dose of 50– 500 mJ/cm2, no erythema due to UV irradiation with wavelength of 222 nm was observed. On the contrary, the minimum erythema dose due to UV irradiation with wavelength of 254 nm is reported to be 10 mJ/cm2. We also confirmed the bactericidal effect against bacteria on human skin with 222nm UV-C.
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