(2016.09)
Bioconjugate Chemistry
Insight into the Working Mechanism of Quenchbody: Transition of the Dye around Antibody Variable Region That Fluoresces upon Antigen Binding.
Hiroyuki Ohashi†‡, Takashi Matsumoto†, Hee-Jin Jeong†§, Jinhua Dong§, Ryoji Abe‡, and Hiroshi Ueda*†§
† Department of Chemistry and Biotechnology, School of Engineering, The University of Tokyo,
‡ Ushio Inc, 6
§ Laboratory for Chemistry and Life Science, Tokyo Institute of Technology,
本研究では、これまで考えられていたQ-bodyのメカニズムである抗原依存的な蛍光色素の動き（クエンチングとデクエンチング）を実験的に確認し、明らかにした
The results clearly suggest that the antigen-dependent fluorescence quenching and recovery of Q-body is caused by the movement of the dye within and around scFv, which moves out of scFv upon binding with its antigen.
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