Journal of Dermatological Science
 VOLUME 93, ISSUE 2, P109-115, FEBRUARY 01, 2019

Dual wavelength 5-aminolevulinic acid photodynamic therapy using a novel flexible light-emitting diode unit 


Hideyuki Masuda1,2, Makoto Kimura1,2, Akiko Nishioka1, Hiroshi Kato1, Akimichi Morita

 1 Department of Geriatric and Environmental Dermatology, Nagoya City University, Graduate School of Medical Sciences, Nagoya, Japan 

 2 USHIO INC, Tokyo, Japan 

In photodynamic therapy (PDT) for skin diseases, 5-aminolevulinic acid (ALA) and Methyl-5-aminolevulinate (MAL) are mainly used as photosensitizers. They are metabolized intracellularly to protoporphyrin IX (PpIX), which has five absorption wavelength peaks at 410 nm, 510 nm, 545 nm, 580 nm and 630 nm. Only red light near 635 nm and blue light near 400 nm have been used as light sources for PDT. However, multiple wavelengths, including wavelengths corresponding to other absorption peaks of PpIX, may improve the efficiency of PDT. Furthermore, since the target disease often occurs on the face, a flexible type light source unit that can be attached to the lesion without unnecessarily exposing mucous membranes such as eyes, nostrils, and mouth is desirable. Therefore, we investigated the enhancement of PDT efficacy by a flexible LED unit having multiple wavelengths using HaCaT cells and a mouse model of skin cancer.  

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