Biomedical Materials, Volume 16, Number 3,2021

Cyclo olefin polymer-based solvent-free mass-productive microphysiological systems


Makoto Yamanaka a, Xiaopeng Wen b, Satoshi Imamura b, Risako Sakai b,Shiho Terada b, and Ken-ichiro Kamei b  

a Incubation Center Organs On Chip Project, Ushio INC.  
b Institute for Integrated Cell-Material Sciences (WPI-iCeMS), Kyoto University. 



 Microphysiological systems (MPS) are expected to replace conventional animal studies in drug screening and toxicity testing as an in vitro evaluation system that enables detailed evaluation closer to the human body. On the other hand, polydimethylsiloxane (PDMS), a silicone rubber-based material, is often used in developing MPS. In addition, organic solvents and adhesives are used in the fabrication of plastic chips, which will cause chemical contaminates on cell culture testing. In this study, we demonstrate that chips made of cyclo-olefin polymer (COP) and fabricated by Photobonding® using vacuum ultraviolet (VUV) light are more suitable for MPS than other chips made with conventional technologies. USHIO expects that its chip fabrication technology will contribute to developing new therapeutic agents and diagnostic methods by realising practical MPS. 


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